Identification of Immune-Related Key Genes as Potential Diagnostic Biomarkers of Sepsis in Children.

ABSTRACT:

Objective

The pathogenesis of sepsis is still unclear due to its complexity, especially in children. This study aimed to analyse the immune microenvironment and regulatory networks related to sepsis in children at the molecular level and to identify key immune-related genes to provide a new basis for the early diagnosis of sepsis.

Methods

The GSE145227 and GSE26440 datasets were downloaded from the Gene Expression Omnibus. The analyses included differentially expressed genes (DEGs), functional enrichment, immune cell infiltration, the competing endogenous RNA (ceRNA) interaction network, weighted gene coexpression network analysis (WGCNA), protein-protein interaction (PPI) network, key gene screening, correlation of sepsis molecular subtypes/immune infiltration with key gene

SUBMITTER: Wang H 

PROVIDER: S-EPMC9015049 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature