A Metabolomics Analysis of Circulating Carotenoids and Breast Cancer Risk.

ABSTRACT:

Background

Higher circulating carotenoids are associated with lower breast cancer risk. The underlying biology remains under-explored.

Methods

We profiled 293 prediagnostic plasma metabolites in a nested case-control study (n = 887 cases) within the Nurses' Health Studies. Associations between circulating carotenoids and metabolites were identified using linear-mixed models (FDR ≤ 0.05), and we further selected metabolites most predictive of carotenoids with LASSO. Metabolic signatures for carotenoids were calculated as weighted sums of LASSO selected metabolites. We further evaluated the metabolic signatures in relation to breast cancer risk using conditional logistic-regression.

Results

We identified 48 to 110 metabolites associated with plasma levels of α-ca

SUBMITTER: Peng C 

PROVIDER: S-EPMC9015159 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature