Gallstone disease and increased risk of mortality: Two large prospective studies in US men and women.

ABSTRACT:

Background and aim

Gallstone disease has been related to a higher prevalence and incidence of chronic conditions, such as dyslipidemia, obesity, and cardiovascular disease (CVD). However, limited data are available regarding whether gallstone disease is related to mortality.

Methods

We examined the relationship of a history of gallstone disease and risk of death, using Cox proportional hazards regression analysis, among 86 030 women from the Nurses' Health Study and 43 949 men from the Health Professionals Follow-up Study.

Results

During the up-to 32 years of follow-up, 34 011 all-cause deaths were confirmed, of which 8138 were CVD deaths and 12 173 were cancer deaths. For the participants with a history of gallstone disease compared with those without, the hazard rat

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC9015210 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature