The effect of vitamin D supplementation on mortality and intensive care unit admission of COVID-19 patients. A systematic review, meta-analysis and meta-regression.

ABSTRACT:

Aims

The aim of this systematic review and meta-analysis was to investigate the effect of vitamin D supplementation on mortality and admission to intensive care unit (ICU) of COVID-19 patients.

Methods

A systematic search of PubMed, Google Scholar, Embase, Web of Science and medRxiv with terms relative to vitamin D supplementation and COVID-19 was conducted on 26 March 2021. Comprehensive Meta-Analysis software was used for the quantitative assessment of data and random-effects model was applied. To investigate the association between the dose of vitamin D and the outcomes of interest, meta-regression analysis was performed.

Results

Two thousand and seventy-eight patients from nine studies with data on mortality were included (583 received vitamin D supplementation, w

SUBMITTER: Tentolouris N 

PROVIDER: S-EPMC9015406 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature