Peripheral innate and adaptive immune cells during COVID-19: Functional neutrophils, pro-inflammatory monocytes, and half-dead lymphocytes.

ABSTRACT:

Background

A better understanding of innate and adaptive cells in COVID-19 is necessary for the development of effective treatment methods and vaccines.

Methods

We studied phenotypic features of innate and adaptive immune cells, oxidative burst, phagocytosis, and apoptosis. One hundred and three patients with COVID-19 were grouped according to their clinical features into the categories of mild (35%), moderate (40.8%), and severe (24.3%).

Results

Monocytes were CD16⁺ pro-inflammatory monocytes and tended to shed their HLA-DR, especially in severe cases (p < 0.01). Neutrophils were mature and functional, although a decline of their CD10 and CD16 was observed (p < 0.01). No defect was found in the reactive oxygen species production and their apoptosis. The pe

SUBMITTER: Eksioglu-Demiralp E 

PROVIDER: S-EPMC9015471 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature