Distinct mutations and lineages of SARS-CoV-2 virus in the early phase of COVID-19 pandemic and subsequent 1-year global expansion.

ABSTRACT: A novel coronavirus, SARS-CoV-2, has caused over 274 million cases and over 5.3 million deaths worldwide since it occurred in December 2019 in Wuhan, China. Here we conceptualized the temporospatial evolutionary and expansion dynamics of SARS-CoV-2 by taking a series of the cross-sectional view of viral genomes from early outbreak in January 2020 in Wuhan to the early phase of global ignition in early April, and finally to the subsequent global expansion by late December 2020. Based on the phylogenetic analysis of the early patients in Wuhan, Wuhan/WH04/2020 is supposed to be a more appropriate reference genome of SARS-CoV-2, instead of the first sequenced genome Wuhan-Hu-1. By scrutinizing the cases from the very early outbreak, we found a viral genotype from the Seafood Market in Wuhan f

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9015543 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature