Bioinformatic Analysis of the Effect of Silver Nanoparticles on Colorectal Cancer Cell Line.

ABSTRACT: Colorectal cancer (CRC) is the most diagnosed cancer with the highest mortality rate each year globally. Although there are treatments for CRC, the development of resistance to therapies decreases the success of treatments. In vitro studies using the Caco-2 cell line have revealed the anticancer properties of silver nanoparticles (AgNPs) as a possible treatment for this disease. This study considered four researches that evaluated the proteomic profiles of cells of the Caco-2 line exposed to AgNPs. We performed a bioinformatics analysis to predict protein-protein interaction, hub genes, Gene Ontology (molecular function, biological process, and cellular components), KEGG pathways, analysis of expression, and immune cell infiltration. For these analyses, the STRING, DAVID, UALCAN, GE

SUBMITTER: Martinez-Esquivias F 

PROVIDER: S-EPMC9015850 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature