Immune checkpoint inhibitor-related thrombocytopenia: incidence, risk factors and effect on survival.

ABSTRACT:

Introduction

Immune checkpoint inhibitors (ICI) are associated with unique immune-related adverse events (irAEs). Immune-related thrombocytopenia (irTCP) is an understudied and poorly understood toxicity; little data are available regarding either risk of irTCP or the effect of irTCP on clinical outcomes of patients treated with ICI.

Methods

We conducted a retrospective review of sequential cancer patients treated with ICI between 2011 and 2017 at our institution. All patients who received ICI alone or in combination with other systemic therapy in any line of treatment were included; those with thrombocytopenia ≥ grade 3 at baseline were excluded. We calculated the incidence of ≥ grade 3 irTCP and overall survival (OS). Patient factors associated with irTCP were assessed.

SUBMITTER: Haddad TC 

PROVIDER: S-EPMC9015999 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature