Targeted Hsp70 fluorescence molecular endoscopy detects dysplasia in Barrett's esophagus.

ABSTRACT:

Purpose

The incidence of esophageal adenocarcinoma (EAC) has been increasing for decades without significant improvements in treatment. Barrett's esophagus (BE) is best established risk factor for EAC, but current surveillance with random biopsies cannot predict progression to cancer in most BE patients due to the low sensitivity and specificity of high-definition white light endoscopy.

Methods

Here, we evaluated the membrane-bound highly specific Hsp70-specific contrast agent Tumor-Penetrating Peptide (Hsp70-TPP) in guided fluorescence molecular endoscopy biopsy.

Results

Hsp70 was significantly overexpressed as determined by IHC in dysplasia and EAC compared with non-dysplastic BE in patient samples (n = 12) and in high-grade dysplastic lesions in a transgenic (L2-IL

SUBMITTER: Fang HY 

PROVIDER: S-EPMC9016004 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature