Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer's disease.

ABSTRACT:

Purpose

Early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) differ in neuropathological burden and type of cognitive deficits. Assessing tau pathology and relative cerebral blood flow (rCBF) measured with [¹⁸F]flortaucipir PET in relation to cognition may help explain these differences between EOAD and LOAD.

Methods

Seventy-nine amyloid-positive individuals with a clinical diagnosis of AD (EOAD: n = 35, age-at-PET = 59 ± 5, MMSE = 23 ± 4; LOAD: n = 44, age-at-PET = 71 ± 5, MMSE = 23 ± 4) underwent a 130-min dynamic [¹⁸F]flortaucipir PET scan and extensive neuropsychological assessment. We extracted binding potentials (BP_ND) and R₁ (proxy of rCBF) from parametric images using receptor parametric mapping,

SUBMITTER: Visser D 

PROVIDER: S-EPMC9016024 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature