[¹⁸F]FDG-PET/CT to prevent futile surgery in indeterminate thyroid nodules: a blinded, randomised controlled multicentre trial.

ABSTRACT:

Purpose

To assess the impact of an [¹⁸F]FDG-PET/CT-driven diagnostic workup to rule out malignancy, avoid futile diagnostic surgeries, and improve patient outcomes in thyroid nodules with indeterminate cytology.

Methods

In this double-blinded, randomised controlled multicentre trial, 132 adult euthyroid patients with scheduled diagnostic surgery for a Bethesda III or IV thyroid nodule underwent [¹⁸F]FDG-PET/CT and were randomised to an [¹⁸F]FDG-PET/CT-driven or diagnostic surgery group. In the [¹⁸F]FDG-PET/CT-driven group, management was based on the [¹⁸F]FDG-PET/CT result: when the index nodule was visually [¹⁸F]FDG-positive, diagnostic surgery was advised; when [¹⁸F]FDG-negative, active surveillan

SUBMITTER: de Koster EJ 

PROVIDER: S-EPMC9016050 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature