Do Early-Life Social, Behavioral, and Health Exposures Increase Later-Life Arthritis Incidence?

ABSTRACT:

Objectives

This study investigates direct and indirect influences of childhood social, behavioral, and health exposures on later-life osteoarthritis and rheumatoid arthritis development.

Methods

Drawing from cumulative inequality theory and six waves of the Health and Retirement Study (2004-2014), we estimate structural equation modeling-based discrete-time survival analysis of the association between six childhood exposure domains and both osteoarthritis and rheumatoid arthritis incidence for men (n = 2720) and women (n = 2974). Using the delta method to test for mediation, we examine indirect effects via selected health-related risks and resources.

Results

Risky adolescent behavior is associated with rheumatoid arthritis incidence for women (h.O.R. = 1

SUBMITTER: Kemp BR 

PROVIDER: S-EPMC9016101 | biostudies-literature | 2022 Aug-Sep

REPOSITORIES: biostudies-literature