Plasma Circulating Tumor DNA in Patients with Primary Central Nervous System Lymphoma.

ABSTRACT:

Purpose

Analysis of circulating tumor DNA (ctDNA) in blood could allow noninvasive genetic analysis of primary tumors. Although there have been unmet needs for noninvasive methods in patients with primary central nervous system lymphoma (PCNSL), it is still not determined whether plasma ctDNA analysis could be useful for patients with PCNSL.

Materials and methods

Targeted deep sequencing of 54 genes was performed in cell-free DNA isolated from plasma samples collected pretreatment, during treatment, and at the end of treatment in 42 consecutively diagnosed PCNSL patients between January 2017 and December 2018.

Results

Targeted sequencing of plasma cell-free DNA detected somatic mutations representing ctDNA in 11 cases (11/41, 27%). The detection of ctDNA was not relat

SUBMITTER: Yoon SE 

PROVIDER: S-EPMC9016302 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature