First computational design using lambda-superstrings and in vivo validation of SARS-CoV-2 vaccine.

ABSTRACT: Coronavirus disease 2019 (COVID-19) is the greatest threat to global health at the present time, and considerable public and private effort is being devoted to fighting this recently emerged disease. Despite the undoubted advances in the development of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, uncertainty remains about their future efficacy and the duration of the immunity induced. It is therefore prudent to continue designing and testing vaccines against this pathogen. In this article we computationally designed two candidate vaccines, one monopeptide and one multipeptide, using a technique involving optimizing lambda-superstrings, which was introduced and developed by our research group. We tested the monopeptide vacci

SUBMITTER: Martinez L 

PROVIDER: S-EPMC9016385 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature