Methamphetamine-Triggered Neurotoxicity in Human Dorsolateral Prefrontal Cortex.

ABSTRACT:

Background

Methamphetamine (MA), is an extremely addictive stimulant that adversely affects the central nervous system. Accumulating evidence indicates that molecular mechanisms such as oxidative stress, apoptosis, and autophagy are involved in the toxicity of MA. Considering experimental animal studies exhibiting MA-induced neurotoxicity, the relevance of these findings needs to be evidently elucidated in human MA users. It is generally assumed that multiple chemical substances released in the brain following MA-induced metabolic activation are primary factors underlying damage of neural cells. Hence, this study aimed to investigate the role of autophagy and apoptosis as well as oxidative stress in the brain of postmortem MA-induced toxicity.

Materials and methods

In this s

SUBMITTER: Zare A 

PROVIDER: S-EPMC9016412 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature