Recurrence of Papillary Thyroid Cancer: A Systematic Appraisal of Risk Factors.

ABSTRACT:

Context

Thyroid cancer recurrence is associated with increased mortality and adverse outcomes. Recurrence risk is currently predicted using clinical tools, often restaging patients after treatment. Detailed understanding of recurrence risk at disease onset could lead to personalized and improved patient care.

Objective

We aimed to perform a comprehensive bioinformatic and experimental analysis of 3 levels of genetic change (mRNA, microRNA, and somatic mutation) apparent in recurrent tumors and construct a new combinatorial prognostic risk model.

Methods

We analyzed The Cancer Genome Atlas data (TCGA) to identify differentially expressed genes (mRNA/microRNA) in 46 recurrent vs 455 nonrecurrent thyroid tumors. Two exonic mutational pipelines were used to identify somat

SUBMITTER: Nieto HR 

PROVIDER: S-EPMC9016467 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature