Prognostic Relevance of ZNF844 and Chr 19p13.2 KRAB-Zinc Finger Proteins in Clear Cell Renal Carcinoma.

ABSTRACT:

Background/aim

Clear-cell renal cell carcinoma (ccRCC) is the most common and aggressive form of all urological cancers, with poor prognosis and high mortality. Despite growing evidence of involvement in carcinogenesis, the role of KRAB-ZFP in ccRCC has not been fully explored. KRAB Zinc finger proteins (KRAB-ZFPs) are the largest family of mammalian transcription regulators. They are differentially expressed in various tissues during cellular development and phenotypic differentiation.

Materials and methods

In this study, the levels of transcripts of ccRCC from The Cancer Genome Atlas (TCGA) dataset were used to identify prognostic biomarkers in this disease.

Results

Using bioinformatics techniques, we demonstrate that approximately 60% of KRAB zinc finger proteins l

SUBMITTER: Heyliger SO 

PROVIDER: S-EPMC9016484 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature