Lack of Association of rs12702634 in RPA3-UMAD1 With Interstitial Lung Diseases in Japanese Rheumatoid Arthritis Patients.
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ABSTRACT: Background
Rheumatoid arthritis (RA) is occasionally complicated with interstitial lung disease (ILD). A recent genome-wide association study of ILD in RA reported an association with the polymorphism rs12702634 in RPA3-UMAD1. We conducted an association study of this variant with ILD in Japanese RA patients to replicate this association.Methods
Genotyping of rs12702634 was performed in 175 RA with ILD and 411 RA without chronic lung disease.Results
No association was detected for rs12702634 with ILD in RA (P = .6369, odds ratio [OR] 1.13, 95% confidence interval [CI] 0.72-1.78). Meta-analysis of these data combined with the data from the recent report showed no significant association (P = .0996, OR 1.52, 95% CI 0.92-2.49).Conclusions
The present study demonstrated no association of RPA3-UMAD1 rs12702634 with ILD in RA, suggesting the heterogeneity of the disease.
SUBMITTER: Higuchi T
PROVIDER: S-EPMC9016516 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Lack of Association of rs12702634 in <i>RPA3-UMAD1</i> With Interstitial Lung Diseases in Japanese Rheumatoid Arthritis Patients.
Higuchi Takashi T Oka Shomi S Furukawa Hiroshi H Shimada Kota K Tohma Shigeto S
Biomarker insights 20220415
<h4>Background</h4>Rheumatoid arthritis (RA) is occasionally complicated with interstitial lung disease (ILD). A recent genome-wide association study of ILD in RA reported an association with the polymorphism rs12702634 in <i>RPA3-UMAD1</i>. We conducted an association study of this variant with ILD in Japanese RA patients to replicate this association.<h4>Methods</h4>Genotyping of rs12702634 was performed in 175 RA with ILD and 411 RA without chronic lung disease.<h4>Results</h4>No association ...[more]
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