Interconversion between Serum Amyloid A Native and Fibril Conformations.

ABSTRACT: Overexpression of serum amyloid A (SAA) can lead to a form of amyloidosis where the fibrils are made of SAA fragments, most often SAA_1-76. Using Replica Exchange with Tunneling, we study the conversion of a SAA_1-76 chain between the folded conformation and a fibril conformation. We find that the basins in the free energy landscape corresponding to the two motifs are separated by barriers of only about 2-3 k _B T. Crucial for the assembly into the fibril structure is the salt bridge 26E-34K that provides a scaffold for forming the fibril conformation.

SUBMITTER: Yasar F 

PROVIDER: S-EPMC9016813 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature