Chiral fluorescent sensor based on H₈-BINOL for the high enantioselective recognition of d- and l-phenylalanine.

ABSTRACT: Phenylalanine an essential aromatic amino acid for humans and animals, cannot be synthesized by humans and animals on their own. However, it synthesizes important neurotransmitters and hormones in the body and is involved in gluconeogenesis and lipid metabolism. Moreover, the two opposite configurations of phenylalanine have different activities. For example, l-phenylalanine is a biologically active optical isomer involved in crucial biological processes, the lack of which will lead to intellectual disability, while d-phenylalanine only acts as a chiral intermediate. In this research, an H₈-BINOL chiral fluorescent sensor modified with 1,2,3-triazole was synthesized in high yield (95%) by nucleophilic substitution and click reaction. The chiral fluorescent sensor showed high ena

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9016822 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature