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Detection of the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium.

ABSTRACT: A new high-level gentamicin resistance gene, designated aph(2")-Ib, was cloned from Enterococcus faecium SF11770. The deduced amino acid sequence of the 897-bp open reading frame of aph(2")-Ib shares homology with the aminoglycoside-modifying enzymes AAC(6')-APH(2"), APH(2")-Ic, and APH(2")-Id. The observed phosphotransferase activity is designated APH(2")-Ib.

SUBMITTER: Kao SJ 

PROVIDER: S-EPMC90169 | biostudies-literature | 2000 Oct

REPOSITORIES: biostudies-literature

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Detection of the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium.

Kao S J SJ   You I I   Clewell D B DB   Donabedian S M SM   Zervos M J MJ   Petrin J J   Shaw K J KJ   Chow J W JW  

Antimicrobial agents and chemotherapy 20001001 10

A new high-level gentamicin resistance gene, designated aph(2")-Ib, was cloned from Enterococcus faecium SF11770. The deduced amino acid sequence of the 897-bp open reading frame of aph(2")-Ib shares homology with the aminoglycoside-modifying enzymes AAC(6')-APH(2"), APH(2")-Ic, and APH(2")-Id. The observed phosphotransferase activity is designated APH(2")-Ib. ...[more]

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