Comparison of two protocols for steroid pulse therapy in patients with IgA nephropathy: a retrospective observational study.

ABSTRACT:

Background

Steroid pulse (SP) therapy is one of the immunosuppressive therapies for immunoglobulin A nephropathy (IgAN). Although there are various protocols of SP therapy in IgAN, the intermittent SP (ISP) and consecutive SP (CSP) protocols are prevalently performed in clinical settings. However, there is a lack of evidence of comparisons of the effects on IgAN between these two protocols.

Methods

A total of 189 patients with IgAN who had received SP therapy were included in this study. They were divided into two groups according to the SP protocols into the intermittent SP (ISP) or consecutive SP (CSP) group as follows: ISP; three-times SP therapy in alternate months, CSP; three-times SP therapy in three consecutive weeks. Kidney function, remission of urinary findings, an

SUBMITTER: Yamatani S 

PROVIDER: S-EPMC9016979 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature