Integrative analysis of mutated genes and mutational processes reveals novel mutational biomarkers in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Recent studies have observed causative mutations in susceptible genes related to colorectal cancer in 10 to 15% of the patients. This highlights the importance of identifying mutations for early detection of this cancer for more effective treatments among high risk individuals. Mutation is considered as the key point in cancer research. Many studies have performed cancer subtyping based on the type of frequently mutated genes, or the proportion of mutational processes. However, to the best of our knowledge, combination of these features has never been used together for this task. This highlights the potential to introduce better and more inclusive subtype classification approaches us

SUBMITTER: Dashti H 

PROVIDER: S-EPMC9017053 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature