Extended two-stage designs for environmental research.

ABSTRACT:

Background

The two-stage design has become a standard tool in environmental epidemiology to model multi-location data. However, its standard form is rather inflexible and poses important limitations for modelling complex risks associated with environmental factors. In this contribution, we illustrate multiple design extensions of the classical two-stage method, all implemented within a unified analytic framework.

Methods

We extended standard two-stage meta-analytic models along the lines of linear mixed-effects models, by allowing location-specific estimates to be pooled through flexible fixed and random-effects structures. This permits the analysis of associations characterised by combinations of multivariate outcomes, hierarchical geographical structures, repeated measures

SUBMITTER: Sera F 

PROVIDER: S-EPMC9017054 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature