Experimental demonstration and pan-structurome prediction of climate-associated riboSNitches in Arabidopsis.

ABSTRACT:

Background

Genome-wide association studies (GWAS) aim to correlate phenotypic changes with genotypic variation. Upon transcription, single nucleotide variants (SNVs) may alter mRNA structure, with potential impacts on transcript stability, macromolecular interactions, and translation. However, plant genomes have not been assessed for the presence of these structure-altering polymorphisms or "riboSNitches."

Results

We experimentally demonstrate the presence of riboSNitches in transcripts of two Arabidopsis genes, ZINC RIBBON 3 (ZR3) and COTTON GOLGI-RELATED 3 (CGR3), which are associated with continentality and temperature variation in the natural environment. These riboSNitches are also associated with differences in the abundance of their respective transcripts, implying a

SUBMITTER: Ferrero-Serrano A 

PROVIDER: S-EPMC9017077 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature