Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis.

ABSTRACT:

Background

Isoniazid-resistant, rifampicin-susceptible (INH-R) tuberculosis is the most common form of drug resistance, and is associated with failure, relapse, and acquired rifampicin resistance if treated with first-line anti-tuberculosis drugs. The aim of the study was to compare success, mortality, and acquired rifampicin resistance in patients with INH-R pulmonary tuberculosis given different durations of rifampicin, ethambutol, and pyrazinamide (REZ); a fluoroquinolone plus 6 months or more of REZ; and streptomycin plus a core regimen of REZ.

Methods

Studies with regimens and outcomes known for individual patients with INH-R tuberculosis were eligible, irrespective of the number of patients if randomised trials, or with at least 20 participants if a cohort study. Studi

SUBMITTER: Fregonese F 

PROVIDER: S-EPMC9017096 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature