Rapid manipulation of mitochondrial morphology in a living cell with iCMM.

ABSTRACT: Engineered synthetic biomolecular devices that integrate elaborate information processing and precisely regulate living cell behavior have potential in various applications. Although devices that directly regulate key biomolecules constituting inherent biological systems exist, no devices have been developed to control intracellular membrane architecture, contributing to the spatiotemporal functions of these biomolecules. This study developed a synthetic biomolecular device, termed inducible counter mitochondrial morphology (iCMM), to manipulate mitochondrial morphology, an emerging informative property for understanding physiopathological cellular behaviors, on a minute timescale by using a chemically inducible dimerization system. Using iCMM, we determined cellular changes by altering mi

SUBMITTER: Miyamoto T 

PROVIDER: S-EPMC9017203 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature