A versatile toolbox for studying cortical physiology in primates.

ABSTRACT: Lesioning and neurophysiological studies have facilitated the elucidation of cortical functions and mechanisms of functional recovery following injury. Clinical translation of such studies is contingent on their employment in non-human primates (NHPs), yet tools for monitoring and modulating cortical physiology are incompatible with conventional lesioning techniques. To address these challenges, we developed a toolbox validated in seven macaques. We introduce the photothrombotic method for inducing focal cortical lesions, a quantitative model for designing experiment-specific lesion profiles and optical coherence tomography angiography (OCTA) for large-scale (~5 cm²) monitoring of vascular dynamics. We integrate these tools with our electrocorticographic array for large-scale mo

SUBMITTER: Khateeb K 

PROVIDER: S-EPMC9017216 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature