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Clinical Isolate of a Multi-Antifungal-Resistant Trichophyton rubrum.

ABSTRACT: The multi-antifungal drug-resistant strain (NUBS21012) of Trichophyton rubrum was isolated from a patient with recurrent tinea corporis. The resistant strain encoded Phe at codon 393 instead of Leu (L393F) in the squalene epoxidase (SQLE) gene. The expression of genes encoding ATP-binding cassette transporter proteins increased in the strain compared to that of other strains. This result provides evidence that ATP-binding cassette transporter proteins are closely associated with azole resistance.

SUBMITTER: Kano R

PROVIDER: S-EPMC9017306 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Clinical Isolate of a Multi-Antifungal-Resistant Trichophyton rubrum.

Kano Rui R Kimura Utako U Noguchi Hiromitsu H Hiruma Masataro M

Antimicrobial agents and chemotherapy 20220328 4

The multi-antifungal drug-resistant strain (NUBS21012) of Trichophyton rubrum was isolated from a patient with recurrent tinea corporis. The resistant strain encoded Phe at codon 393 instead of Leu (L393F) in the squalene epoxidase (<i>SQLE</i>) gene. The expression of genes encoding ATP-binding cassette transporter proteins increased in the strain compared to that of other strains. This result provides evidence that ATP-binding cassette transporter proteins are closely associated with azole res ...[more]

PMID: 35341316

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