Clinical Isolate of a Multi-Antifungal-Resistant Trichophyton rubrum.

ABSTRACT: The multi-antifungal drug-resistant strain (NUBS21012) of Trichophyton rubrum was isolated from a patient with recurrent tinea corporis. The resistant strain encoded Phe at codon 393 instead of Leu (L393F) in the squalene epoxidase (SQLE) gene. The expression of genes encoding ATP-binding cassette transporter proteins increased in the strain compared to that of other strains. This result provides evidence that ATP-binding cassette transporter proteins are closely associated with azole resistance.

SUBMITTER: Kano R 

PROVIDER: S-EPMC9017306 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature