Heritability Enrichment Implicates Microglia in Parkinson's Disease Pathogenesis.

ABSTRACT:

Objective

Understanding how different parts of the immune system contribute to pathogenesis in Parkinson's disease is a burning challenge with important therapeutic implications. We studied enrichment of common variant heritability for Parkinson's disease stratified by immune and brain cell types.

Methods

We used summary statistics from the most recent meta-analysis of genomewide association studies in Parkinson's disease and partitioned heritability using linkage disequilibrium score regression, stratified for specific cell types, as defined by open chromatin regions. We also validated enrichment results using a polygenic risk score approach and intersected disease-associated variants with epigenetic data and expression quantitative loci to nominate and explore a putative m

SUBMITTER: Andersen MS 

PROVIDER: S-EPMC9017316 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature