Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson's Disease.

ABSTRACT:

Background

Epidemiological studies have reported an association between Parkinson's disease (PD) and restless legs syndrome.

Objectives

We aimed to use genetic data to study whether these 2 disorders are causally linked or share genetic architecture.

Methods

We performed two-sample Mendelian randomization and linkage disequilibrium score regression using summary statistics from recent genome-wide meta-analyses of PD and restless legs syndrome.

Results

We found no evidence for a causal relationship between restless legs syndrome (as the exposure) and PD (as the outcome, inverse variance-weighted; b = -0.003, SE = 0.031, P = 0.916; F statistic = 217.5). Reverse Mendelian randomization also did not demonstrate any causal effect of PD on restless legs syndrome (inv

SUBMITTER: Estiar MA 

PROVIDER: S-EPMC9017317 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature