Type 2 Diabetes as a Determinant of Parkinson's Disease Risk and Progression.

ABSTRACT:

Background

Type 2 diabetes (T2DM) and Parkinson's disease (PD) are prevalent diseases that affect an aging population. Previous systematic reviews and meta-analyses have explored the relationship between diabetes and the risk of PD, but the results have been conflicting.

Objective

The objective was to investigate T2DM as a determinant of PD through a meta-analysis of observational and genetic summary data.

Methods

A systematic review and meta-analysis of observational studies was undertaken by searching 6 databases. We selected the highest-quality studies investigating the association of T2DM with PD risk and progression. We then used Mendelian randomization (MR) to investigate the causal effects of genetic liability toward T2DM on PD risk and progression, using summa

SUBMITTER: Chohan H 

PROVIDER: S-EPMC9017318 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature