Preconditioning process for dermal tissue decellularization using electroporation with sonication.

ABSTRACT: Decellularization to produce bioscaffolds composed of the extracellular matrix (ECM) uses enzymatic, chemical and physical methods to remove antigens and cellular components from tissues. Effective decellularization methods depend on the characteristics of tissues, and in particular, tissues with dense, complex structure and abundant lipid content are difficult to completely decellularize. Our study enables future research on the development of methods and treatments for fabricating bioscaffolds via decellularization of complex and rigid skin tissues, which are not commonly considered for decellularization to date as their structural and functional characteristics could not be preserved after severe decellularization. In this study, decellularization of human dermal tissue was done by a co

SUBMITTER: Koo MA 

PROVIDER: S-EPMC9017362 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature