Clinical Predictors and Prognosis of Recurrent IgA Nephropathy in the Kidney Allograft.

ABSTRACT:

Introduction

Although IgA nephropathy (IgAN) is the most common recurrent glomerulonephritis encountered in the kidney allograft, the clinical and immunogenetic characteristics remain poorly understood. We sought to study determinants and prognosis of recurrent IgAN with special focus on HLA antigens.

Materials and methods

Between 2005 and 2019, we identified 282 transplanted patients with failure secondary to IgAN from two North American and one European Medical Centers, including 80 with recurrent IgAN and 202 without recurrence. Prevalence of HLA antigens was compared to external healthy controls of European ancestry (n=15,740). Graft survival was assessed by Kaplan-Meier method and log rank test. Cox proportional hazards were used for multivariable analyses.

Results</

SUBMITTER: Kavanagh CR 

PROVIDER: S-EPMC9017582 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature