MiR-4431 targets TRIP10/PRKD1 and impairs glucose metabolism.

ABSTRACT:

Aim/introduction

Obesity is considered an important risk factor for many metabolic disorders, especially type 2 diabetes mellitus, and microRNAs (miRNAs) play a vital role in the development of type 2 diabetes mellitus. Therefore, we conducted this study to investigate the role of miR-4431 in the obesity-associated pathobiology of type 2 diabetes mellitus.

Materials and methods

Subjects were divided into normal control (n = 36), obese (n = 36), and type 2 diabetes mellitus (n = 12) groups, and serum miR-4431 levels were analyzed. Adenovirus-vectored miR-4431 mimic or sponge was intraperitoneally injected into the normal diet group and the high-fat diet group (HFD) mice to investigate glucose tolerance, insulin sensitivity, and lipid levels. The downstream target genes of miR

SUBMITTER: Pan C 

PROVIDER: S-EPMC9017615 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature