High glucose enhances lipopolysaccharide-induced inflammation in cultured BV2 microglial cell line.

ABSTRACT:

Introduction

Diabetes mellitus emerges as a global health crisis and is related to the development of neurodegenerative diseases. Microglia, a population of macrophages-like cells, govern immune defense in the central nervous system. Activated microglia are known to play active roles in the pathogenesis of neurodegenerative diseases.

Methods

This study aimed to investigate the effects of high glucose on low-dose lipopolysaccharide (LPS)-induced activations of inflammation-related signaling molecules in cultured BV2 microglial cells.

Results

Compared to cells cultured in the normal glucose medium (NGM, 5.5 mM), the LPS-induced activation of NF-κB lasted longer in cells cultured in high glucose medium (HGM, 25 mM). HGM also enhanced the expression of inducible nitric ox

SUBMITTER: Hung HC 

PROVIDER: S-EPMC9017628 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature