Sequential Pathway Inference for Multimodal Neuroimaging Analysis.

ABSTRACT: Motivated by a multimodal neuroimaging study for Alzheimer's disease, in this article, we study the inference problem, i.e., hypothesis testing, of sequential mediation analysis. The existing sequential mediation solutions mostly focus on sparse estimation, while hypothesis testing is an utterly different and more challenging problem. Meanwhile, the few mediation testing solutions often ignore the potential dependency among the mediators, or cannot be applied to the sequential problem directly. We propose a statistical inference procedure to test mediation pathways when there are sequentially ordered multiple data modalities and each modality involves multiple mediators. We allow the mediators to be conditionally dependent, and the number of mediators within each modality to diverge with t

SUBMITTER: Li L 

PROVIDER: S-EPMC9017676 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature