Rapid evolution of SARS-CoV-2 challenges human defenses.

ABSTRACT: The race between pathogens and their hosts is a major evolutionary driver, where both reshuffle their genomes to overcome and reorganize the defenses for infection, respectively. Evolutionary theory helps formulate predictions on the future evolutionary dynamics of SARS-CoV-2, which can be monitored through unprecedented real-time tracking of SARS-CoV-2 population genomics at the global scale. Here we quantify the accelerating evolution of SARS-CoV-2 by tracking the SARS-CoV-2 mutation globally, with a focus on the Receptor Binding Domain (RBD) of the spike protein determining infection success. We estimate that the > 820 million people that had been infected by October 5, 2021, produced up to 10²¹ copies of the virus, with 12 new effective RBD variants appearing, on average, da

SUBMITTER: Duarte CM 

PROVIDER: S-EPMC9017738 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature