Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma.

ABSTRACT:

Background

Resistance to ferroptosis, a regulated cell death caused by iron-dependent excessive accumulation of lipid peroxides, has recently been linked to lung adenocarcinoma (LUAD). Intracellular antioxidant systems are required for protection against ferroptosis. The purpose of the present study was to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.

Methods

Established human lung fibroblasts MRC-5, WI38, and human LUAD H1650, PC9, H1975, H358, A549, and H1299 cell lines, tumor and matched normal adjacent tissues of LUAD, and plasma from healthy individuals and LUAD patients were used in this study. Immunohistochemistry and immunoblotting were used to analyze protein expression, and quantitative reverse transcription-PCR was used t

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9017758 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature