VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei.

ABSTRACT: The Trypanosoma (T) brucei life cycle alternates between the tsetse fly vector and the mammalian host. In the insect, T. brucei undergoes several developmental stages until it reaches the salivary gland and differentiates into the metacyclic form, which is capable of infecting the next mammalian host. Mammalian infectivity is dependent on expression of the metacyclic variant surface glycoprotein genes as the cells develop into mature metacyclics. The VEX complex is essential for monoallelic variant surface glycoprotein expression in T. brucei bloodstream form, however, initiation of expression of the surface proteins genes during metacyclic differentiation is poorly understood. To better understand the transition to mature metacyclics and the control of metacycl

SUBMITTER: Tihon E 

PROVIDER: S-EPMC9017762 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature