Longitudinal deep sequencing informs vector selection and future deployment strategies for transmissible vaccines.

ABSTRACT: Vaccination is a powerful tool in combating infectious diseases of humans and companion animals. In most wildlife, including reservoirs of emerging human diseases, achieving sufficient vaccine coverage to mitigate disease burdens remains logistically unattainable. Virally vectored "transmissible" vaccines that deliberately spread among hosts are a potentially transformative, but still theoretical, solution to the challenge of immunising inaccessible wildlife. Progress towards real-world application is frustrated by the absence of frameworks to guide vector selection and vaccine deployment prior to major in vitro and in vivo investments in vaccine engineering and testing. Here, we performed deep sequencing on field-collected samples of Desmodus rotundus betaherpesvirus (DrBHV), a candidate

SUBMITTER: Griffiths ME 

PROVIDER: S-EPMC9017877 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature