Simulated actin reorganization mediated by motor proteins.

ABSTRACT: Cortical actin networks are highly dynamic and play critical roles in shaping the mechanical properties of cells. The actin cytoskeleton undergoes significant reorganization in many different contexts, including during directed cell migration and over the course of the cell cycle, when cortical actin can transition between different configurations such as open patched meshworks, homogeneous distributions, and aligned bundles. Several types of myosin motor proteins, characterized by different kinetic parameters, have been involved in this reorganization of actin filaments. Given the limitations in studying the interactions of actin with myosin in vivo, we propose stochastic agent-based models and develop a set of data analysis measures to assess how myosin motor proteins mediate various act

SUBMITTER: Ciocanel MV 

PROVIDER: S-EPMC9017880 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature