Mechanisms and clinical implications of endothelium-dependent vasomotor dysfunction in coronary microvasculature.

ABSTRACT: Coronary microvascular disease (CMD), which affects the arterioles and capillary endothelium that regulate myocardial perfusion, is an increasingly recognized source of morbidity and mortality, particularly in the setting of metabolic syndrome. The coronary endothelium plays a pivotal role in maintaining homeostasis, though factors such as diabetes, hypertension, hyperlipidemia, and obesity can contribute to endothelial injury and consequently arteriolar vasomotor dysfunction. These disturbances in the coronary microvasculature clinically manifest as diminished coronary flow reserve, which is a known independent risk factor for cardiac death, even in the absence of macrovascular atherosclerotic disease. Therefore, a growing body of literature has examined the molecular mechanisms by which

SUBMITTER: Sabe SA 

PROVIDER: S-EPMC9018047 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature