Regulation of prefrontal patterning and connectivity by retinoic acid.

ABSTRACT: The prefrontal cortex (PFC) and its connections with the mediodorsal thalamus are crucial for cognitive flexibility and working memory¹ and are thought to be altered in disorders such as autism^2,3 and schizophrenia^4,5. Although developmental mechanisms that govern the regional patterning of the cerebral cortex have been characterized in rodents^6-9, the mechanisms that underlie the development of PFC-mediodorsal thalamus connectivity and the lateral expansion of the PFC with a distinct granular layer 4 in primates^10,11 remain unknown. Here we report an anterior (frontal) to posterior (temporal), PFC-enriched gradient of retinoic acid, a signalling molecule that regulates neural development and function^12-15, and we identify g

SUBMITTER: Shibata M 

PROVIDER: S-EPMC9018119 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature