Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis.

ABSTRACT: The similarities and differences between nervous systems of various species result from developmental constraints and specific adaptations^1-4. Comparative analyses of the prefrontal cortex (PFC), a cerebral cortex region involved in higher-order cognition and complex social behaviours, have identified true and potential human-specific structural and molecular specializations^4-8, such as an exaggerated PFC-enriched anterior-posterior dendritic spine density gradient⁵. These changes are probably mediated by divergence in spatiotemporal gene regulation^9-17, which is particularly prominent in the midfetal human cortex^15,18-20. Here we analysed human and macaque transcriptomic data^15,20 and identified a transient PFC-enriched and

SUBMITTER: Shibata M 

PROVIDER: S-EPMC9018127 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature