Air pollution and risk of chronic obstructed pulmonary disease: The modifying effect of genetic susceptibility and lifestyle.

ABSTRACT:

Background

The effect of long-term exposure to air pollution on the development of chronic obstructive pulmonary disease (COPD) is still controversial, and the role of the interactions of air pollution with genetic risk and lifestyle in COPD risk is unclear.

Methods

We included 452762 participants derived from the UK Biobank. Annual concentrations of air pollutions, including particle matter (PM_2.5, PM₁₀), nitrogen oxides (NO_x), and nitrogen dioxide (NO₂), were assessed using land-use regression model. We applied Cox proportional hazard model to evaluate the associations between air pollution and COPD risk. In addition, we constructed a polygenic risk score and a lifestyle score, and assessed whether genetic susceptibility and life

SUBMITTER: Wang L 

PROVIDER: S-EPMC9018147 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature