Unbiased inference of the fitness landscape ruggedness from imprecise fitness estimates.

ABSTRACT: Fitness landscapes map genotypes to their corresponding fitness under given environments and allow explaining and predicting evolutionary trajectories. Of particular interest is the landscape ruggedness or the unevenness of the landscape, because it impacts many aspects of evolution such as the likelihood that a population is trapped in a local fitness peak. Although the ruggedness has been inferred from a number of empirically mapped fitness landscapes, it is unclear to what extent this inference is affected by fitness estimation error, which is inevitable in the experimental determination of fitness landscapes. Here, we address this question by simulating fitness landscapes under various theoretical models, with or without fitness estimation error. We find that all eight examined measure

SUBMITTER: Song S 

PROVIDER: S-EPMC9018209 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature