Disruption of mitochondrial quality control genes promotes caspase-resistant cell survival following apoptotic stimuli.

ABSTRACT: In cells undergoing cell-intrinsic apoptosis, mitochondrial outer membrane permeabilization (MOMP) typically marks an irreversible step in the cell death process. However, in some cases, a subpopulation of treated cells can exhibit a sublethal response, termed "minority MOMP." In this phenomenon, the affected cells survive, despite a low level of caspase activation and subsequent limited activation of the endonuclease caspase-activated DNase (DNA fragmentation factor subunit beta). Consequently, these cells can experience DNA damage, increasing the probability of oncogenesis. However, little is known about the minority MOMP response. To discover genes that affect the MOMP response in individual cells, we conducted an imaging-based phenotypic siRNA screen. We identified multiple candidate g

SUBMITTER: Kushnareva Y 

PROVIDER: S-EPMC9018395 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature