Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy.

ABSTRACT:

Background

Differentiating between glomerular and tubulointerstitial diseases can guide selection of appropriate patients for kidney biopsy. The aim of this study is to identify urine tests that can differentiate between these histological diagnoses.

Methods

In this sub-study of a prospectively enrolled cohort of participants with urine samples concurrent with their kidney biopsy, we tested the association of 24 features on urinalysis, urine sediment microscopy, and biomarkers of glomerular and tubular injury and inflammation with histological diagnosis of glomerular or tubulointerstitial disease. We selected a combination of features associated with glomerular disease using stepwise forward and backward regression, and LASSO algorithm after dividing the cohort into training

SUBMITTER: Tran AC 

PROVIDER: S-EPMC9018443 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature