Genomic Features of Muscle-invasive Bladder Cancer Arising After Prostate Radiotherapy.

ABSTRACT:

Background

Muscle-invasive bladder cancer (MIBC) is a rare but serious event following definitive radiation for prostate cancer. Radiation-associated MIBC (RA-MIBC) can be difficult to manage given the challenges of delivering definitive therapy to a previously irradiated pelvis. The genomic landscape of RA-MIBC and whether it is distinct from non-RA-MIBC are unknown.

Objective

To define mutational features of RA-MIBC and compare the genomic landscape of RA-MIBC with that of non-RA-MIBC.

Design, setting, and participants

We identified patients from our institution who received radiotherapy for prostate cancer and subsequently developed MIBC.

Outcome measurements and statistical analysis

We performed whole exome sequencing of bladder tumors from RA-MIBC patients

SUBMITTER: Mossanen M 

PROVIDER: S-EPMC9018481 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature